Drug interactions
Dexrazoxane + Hydroxycarbamide
Severity: Moderate
Dexrazoxane and Hydroxycarbamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexrazoxane can cause myelosuppression of its own, mostly seen with the chemotherapy it accompanies. Together with hydroxyurea, blood count suppression may be greater.
What this interaction means in plain words
Dexrazoxane and Hydroxycarbamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexrazoxane belongs to Miscellaneous; Hydroxycarbamide belongs to Oncology.
Why it happens
Additive myelosuppressive effects.
What to do
Monitor complete blood counts regularly. Adjust hydroxyurea dose if significant cytopenias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxycarbamide
- Didanosine + Hydroxycarbamide Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Adenovirus types 4 and 7 live + Hydroxycarbamide Major
- Axicabtagene ciloleucel + Hydroxycarbamide Major
- Bcg intravesical live + Hydroxycarbamide Major
- Bcg vaccine live + Hydroxycarbamide Major
Other interactions of Dexrazoxane
- Dexrazoxane + Lomustine Moderate
- Dexrazoxane + Zidovudine Moderate
Frequently asked questions
Can I take Dexrazoxane with Hydroxycarbamide?
MediHelp rates the interaction as moderate. Dexrazoxane and Hydroxycarbamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexrazoxane can cause myelosuppression of its own, mostly seen with the chemotherapy it accompanies. Together with hydroxyurea, blood count suppression may be greater.
How serious is the interaction between Dexrazoxane and Hydroxycarbamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly. Adjust hydroxyurea dose if significant cytopenias develop.
What other medicines interact with Hydroxycarbamide?
MediHelp also lists interactions of Hydroxycarbamide with, for example, Didanosine, Stavudine, Adenovirus types 4 and 7 live. The full list is on the Hydroxycarbamide page.
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