Drug interactions
Dextroamphetamine + Dronedarone
Severity: Minor
Dextroamphetamine and Dronedarone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits CYP2D6, which contributes to amphetamine metabolism, so dextroamphetamine levels may rise slightly. Amphetamines can also provoke tachyarrhythmias, which is relevant in patients taking antiarrhythmics.
What this interaction means in plain words
Dextroamphetamine and Dronedarone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dextroamphetamine belongs to Central Nervous System; Dronedarone belongs to Cardiovascular.
Why it happens
Dronedarone inhibits CYP2D6 metabolism of dextroamphetamine; pharmacodynamic opposition on heart rhythm is also possible.
What to do
Monitor heart rate, blood pressure and palpitations. Adjust the dextroamphetamine dose if stimulant adverse effects increase.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Dronedarone?
MediHelp rates the interaction as minor. Dextroamphetamine and Dronedarone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dronedarone inhibits CYP2D6, which contributes to amphetamine metabolism, so dextroamphetamine levels may rise slightly. Amphetamines can also provoke tachyarrhythmias, which is relevant in patients taking antiarrhythmics.
How serious is the interaction between Dextroamphetamine and Dronedarone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and palpitations. Adjust the dextroamphetamine dose if stimulant adverse effects increase.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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