Drug interactions
Dextroamphetamine + Ephedrine
Severity: Moderate
Dextroamphetamine and Ephedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are sympathomimetics that release norepinephrine, so combining them leads to additive rises in blood pressure and heart rate and more stimulation. Patients with hypertension, coronary disease or arrhythmia are at greatest risk.
What this interaction means in plain words
Dextroamphetamine and Ephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Ephedrine belongs to Cardiovascular.
Why it happens
Additive indirect sympathomimetic activity via norepinephrine release and some direct adrenergic agonism.
What to do
Avoid unnecessary concurrent use, including over-the-counter ephedrine products. If needed, monitor blood pressure and heart rate and use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Ephedrine?
MediHelp rates the interaction as moderate. Dextroamphetamine and Ephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are sympathomimetics that release norepinephrine, so combining them leads to additive rises in blood pressure and heart rate and more stimulation. Patients with hypertension, coronary disease or arrhythmia are at greatest risk.
How serious is the interaction between Dextroamphetamine and Ephedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary concurrent use, including over-the-counter ephedrine products. If needed, monitor blood pressure and heart rate and use the lowest effective doses.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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