Drug interactions
Dextroamphetamine + Haloperidol
Severity: Moderate
Dextroamphetamine and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol blocks dopamine D2 receptors and can counteract the dopaminergic effects of amphetamine, and the stimulant may in turn worsen psychotic symptoms. Both drugs can also influence cardiac rhythm, with haloperidol prolonging the QT interval.
What this interaction means in plain words
Dextroamphetamine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Haloperidol belongs to Central Nervous System.
Why it happens
Pharmacodynamic opposition at dopamine receptors, with possible additive cardiac effects.
What to do
Monitor psychiatric status and ECG or QT interval where risk factors exist, and reassess the stimulant if psychosis worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Haloperidol?
MediHelp rates the interaction as moderate. Dextroamphetamine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol blocks dopamine D2 receptors and can counteract the dopaminergic effects of amphetamine, and the stimulant may in turn worsen psychotic symptoms. Both drugs can also influence cardiac rhythm, with haloperidol prolonging the QT interval.
How serious is the interaction between Dextroamphetamine and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric status and ECG or QT interval where risk factors exist, and reassess the stimulant if psychosis worsens.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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