Drug interactions
Dextroamphetamine + Hydromorphone
Severity: Minor
Dextroamphetamine and Hydromorphone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextroamphetamine is a stimulant that may partially offset opioid sedation while potentially enhancing opioid analgesia, but the net effect is unpredictable. Stimulant effects can mask sedation, and cardiovascular stimulation may add to adverse effects.
What this interaction means in plain words
Dextroamphetamine and Hydromorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dextroamphetamine belongs to Central Nervous System; Hydromorphone belongs to Musculoskeletal.
Why it happens
Opposing CNS stimulant and depressant effects; the clinical interplay is not well established.
What to do
Monitor analgesia, alertness and heart rate, and do not rely on the stimulant to counteract opioid-induced respiratory depression.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Hydromorphone?
MediHelp rates the interaction as minor. Dextroamphetamine and Hydromorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dextroamphetamine is a stimulant that may partially offset opioid sedation while potentially enhancing opioid analgesia, but the net effect is unpredictable. Stimulant effects can mask sedation, and cardiovascular stimulation may add to adverse effects.
How serious is the interaction between Dextroamphetamine and Hydromorphone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesia, alertness and heart rate, and do not rely on the stimulant to counteract opioid-induced respiratory depression.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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