Drug interactions
Dextroamphetamine + Hydroxyzine
Severity: Minor
Dextroamphetamine and Hydroxyzine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine is a sedating antihistamine that may offset the alerting effect of dextroamphetamine, and the stimulant may mask drowsiness. Hydroxyzine also prolongs the QT interval, and stimulants can raise heart rate, so cardiac effects may add.
What this interaction means in plain words
Dextroamphetamine and Hydroxyzine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dextroamphetamine belongs to Central Nervous System; Hydroxyzine belongs to Respiratory.
Why it happens
Opposing CNS effects of antihistaminic sedation and amphetamine stimulation, with minor additive cardiac effects.
What to do
Monitor for reduced efficacy of either drug and palpitations, and check the ECG in patients with other QT risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Dextroamphetamine with Hydroxyzine?
MediHelp rates the interaction as minor. Dextroamphetamine and Hydroxyzine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydroxyzine is a sedating antihistamine that may offset the alerting effect of dextroamphetamine, and the stimulant may mask drowsiness. Hydroxyzine also prolongs the QT interval, and stimulants can raise heart rate, so cardiac effects may add.
How serious is the interaction between Dextroamphetamine and Hydroxyzine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced efficacy of either drug and palpitations, and check the ECG in patients with other QT risk factors.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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