Drug interactions
Dextroamphetamine + Iloperidone
Severity: Moderate
Dextroamphetamine and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone prolongs the QT interval and its dopamine antagonism opposes the effects of amphetamine, while amphetamine can cause tachycardia and arrhythmia. The therapeutic effects of each drug may be reduced and cardiac risk may rise.
What this interaction means in plain words
Dextroamphetamine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Iloperidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine receptors plus additive cardiac effects.
What to do
Monitor clinical response to both drugs and obtain an ECG if other QT risk factors exist. Correct electrolyte abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Dextroamphetamine with Iloperidone?
MediHelp rates the interaction as moderate. Dextroamphetamine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone prolongs the QT interval and its dopamine antagonism opposes the effects of amphetamine, while amphetamine can cause tachycardia and arrhythmia. The therapeutic effects of each drug may be reduced and cardiac risk may rise.
How serious is the interaction between Dextroamphetamine and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to both drugs and obtain an ECG if other QT risk factors exist. Correct electrolyte abnormalities.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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