Drug interactions
Dextroamphetamine + Midodrine
Severity: Major
Dextroamphetamine and Midodrine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midodrine is an alpha-1 agonist that raises blood pressure, and amphetamines also elevate blood pressure and heart rate. Combined use may cause excessive hypertension, supine hypertension and reflex bradycardia or arrhythmia.
What this interaction means in plain words
Dextroamphetamine and Midodrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dextroamphetamine belongs to Central Nervous System; Midodrine belongs to Miscellaneous.
Why it happens
Additive vasopressor effects from direct alpha-1 agonism and indirect amphetamine sympathomimetic action.
What to do
Avoid if possible; otherwise monitor blood pressure including supine readings and reduce the midodrine dose if hypertension develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dextroamphetamine and Midodrine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
- Ergotamine + Midodrine Major
Frequently asked questions
Can I take Dextroamphetamine with Midodrine?
MediHelp rates the interaction as major. Dextroamphetamine and Midodrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Midodrine is an alpha-1 agonist that raises blood pressure, and amphetamines also elevate blood pressure and heart rate. Combined use may cause excessive hypertension, supine hypertension and reflex bradycardia or arrhythmia.
How serious is the interaction between Dextroamphetamine and Midodrine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor blood pressure including supine readings and reduce the midodrine dose if hypertension develops.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
