Drug interactions
Midodrine + Tranylcypromine
Severity: Contraindicated
Midodrine and Tranylcypromine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midodrine is an alpha-1 agonist that raises blood pressure, and an MAO inhibitor can potentiate sympathomimetic pressor effects. The result may be severe hypertension or hypertensive crisis.
What this interaction means in plain words
Midodrine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Midodrine belongs to Miscellaneous; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive pressor effects from alpha-1 agonism and MAO inhibition, which augments adrenergic tone.
What to do
Avoid the combination. If a vasopressor is needed in a patient on an MAO inhibitor, choose an approach with close blood pressure monitoring in a supervised setting.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
- Ergotamine + Midodrine Major
Frequently asked questions
Can I take Midodrine with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Midodrine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Midodrine is an alpha-1 agonist that raises blood pressure, and an MAO inhibitor can potentiate sympathomimetic pressor effects. The result may be severe hypertension or hypertensive crisis.
How serious is the interaction between Midodrine and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If a vasopressor is needed in a patient on an MAO inhibitor, choose an approach with close blood pressure monitoring in a supervised setting.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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