Drug interactions
Midodrine + Phenelzine
Severity: Contraindicated
Midodrine and Phenelzine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midodrine is an alpha-1 agonist, and its pressor effect can be exaggerated in patients on an MAOI, which potentiates adrenergic stimulation. Severe hypertension or hypertensive crisis is a concern. The pairing should be avoided.
What this interaction means in plain words
Midodrine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Midodrine belongs to Miscellaneous; Phenelzine belongs to Central Nervous System.
Why it happens
Additive pressor effect from alpha-1 agonism with MAOI-enhanced sympathetic activity.
What to do
Avoid concurrent use and allow 14 days after stopping phenelzine before midodrine. Select another approach for orthostatic hypotension.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
- Ergotamine + Midodrine Major
Frequently asked questions
Can I take Midodrine with Phenelzine?
MediHelp rates the interaction as contraindicated. Midodrine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Midodrine is an alpha-1 agonist, and its pressor effect can be exaggerated in patients on an MAOI, which potentiates adrenergic stimulation. Severe hypertension or hypertensive crisis is a concern. The pairing should be avoided.
How serious is the interaction between Midodrine and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and allow 14 days after stopping phenelzine before midodrine. Select another approach for orthostatic hypotension.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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