Drug reference
midodrine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Miscellaneous (Miscellaneous)
Mechanism of action
Alpha-1 selective adrenergic agonist; increases peripheral vascular resistance; arteriolar and venous tone increases and results in a rise in sitting, standing, and supine systolic and diastolic blood pressure in patients with orthostatic hypotension
Common side effects
- Pruritus
- Chills
- Paresthesia
- Piloerection
- Supine hypertension
- Urinary retention or urgency
- Pain, including abdominal pain
Known interactions (3)
- isocarboxazid + midodrine Contraindicated
- ergotamine + midodrine Major
- cabergoline + midodrine Moderate
Related conditions
Frequently asked questions
What drug class is midodrine?
midodrine belongs to: Miscellaneous.
How does midodrine work?
Alpha-1 selective adrenergic agonist; increases peripheral vascular resistance; arteriolar and venous tone increases and results in a rise in sitting, standing, and supine systolic and diastolic blood pressure in patients with orthostatic hypotension
What are the common side effects of midodrine?
Pruritus, Chills, Paresthesia, Piloerection, Supine hypertension, Urinary retention or urgency, Pain, including abdominal pain
Which drugs interact with midodrine?
isocarboxazid, ergotamine, cabergoline
Full monographs, dosing and an interaction checker in the MediHelp app
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