Drug interactions
Dextroamphetamine + Perphenazine
Severity: Moderate
Dextroamphetamine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine blocks dopamine receptors and can oppose the effects of amphetamine, while stimulants may worsen psychosis. Phenothiazines can also prolong the QT interval, adding to cardiac concerns with stimulants.
What this interaction means in plain words
Dextroamphetamine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine receptors, with possible additive cardiac effects.
What to do
Monitor mental state, heart rate and ECG in at-risk patients, and reassess the stimulant if psychosis worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Dextroamphetamine with Perphenazine?
MediHelp rates the interaction as moderate. Dextroamphetamine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine blocks dopamine receptors and can oppose the effects of amphetamine, while stimulants may worsen psychosis. Phenothiazines can also prolong the QT interval, adding to cardiac concerns with stimulants.
How serious is the interaction between Dextroamphetamine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor mental state, heart rate and ECG in at-risk patients, and reassess the stimulant if psychosis worsens.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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