Drug interactions
Dextroamphetamine + Tazemetostat
Severity: Minor
Dextroamphetamine and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak-to-moderate CYP3A4 inducer, but dextroamphetamine is mainly cleared by renal excretion and CYP2D6 rather than CYP3A4. A clinically meaningful reduction in its effect is not expected.
What this interaction means in plain words
Dextroamphetamine and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dextroamphetamine belongs to Central Nervous System; Tazemetostat belongs to Miscellaneous.
Why it happens
Possible modest CYP3A4 induction; CYP3A4 is a minor pathway for dextroamphetamine.
What to do
No dose adjustment is needed; monitor clinical response to dextroamphetamine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Dextroamphetamine with Tazemetostat?
MediHelp rates the interaction as minor. Dextroamphetamine and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak-to-moderate CYP3A4 inducer, but dextroamphetamine is mainly cleared by renal excretion and CYP2D6 rather than CYP3A4. A clinically meaningful reduction in its effect is not expected.
How serious is the interaction between Dextroamphetamine and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor clinical response to dextroamphetamine.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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