Drug interactions
Dextroamphetamine + Zolmitriptan
Severity: Moderate
Dextroamphetamine and Zolmitriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amphetamines enhance serotonergic and noradrenergic transmission, and triptans act at serotonin receptors. Co-administration could add to serotonergic effects and blood pressure elevation, and rarely lead to serotonin syndrome.
What this interaction means in plain words
Dextroamphetamine and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dextroamphetamine belongs to Central Nervous System; Zolmitriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic activity (amphetamine-induced serotonin release plus 5-HT1B/1D agonism) with additive pressor effects.
What to do
Counsel the patient to report agitation, tremor, sweating, diarrhea or fever promptly. Monitor blood pressure and stop one agent if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Frequently asked questions
Can I take Dextroamphetamine with Zolmitriptan?
MediHelp rates the interaction as moderate. Dextroamphetamine and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amphetamines enhance serotonergic and noradrenergic transmission, and triptans act at serotonin receptors. Co-administration could add to serotonergic effects and blood pressure elevation, and rarely lead to serotonin syndrome.
How serious is the interaction between Dextroamphetamine and Zolmitriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report agitation, tremor, sweating, diarrhea or fever promptly. Monitor blood pressure and stop one agent if serotonin syndrome is suspected.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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