Drug interactions
Dextroamphetamine transdermal + Mirabegron
Severity: Moderate
Dextroamphetamine transdermal and Mirabegron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dextroamphetamine is partly metabolized by CYP2D6, so mirabegron may increase amphetamine exposure. This could heighten sympathomimetic effects and the risk of serotonin syndrome, although the clinical impact is likely modest.
What this interaction means in plain words
Dextroamphetamine transdermal and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mirabegron inhibits CYP2D6, decreasing amphetamine clearance.
What to do
Start with a lower amphetamine dose and monitor heart rate, blood pressure and signs of serotonin toxicity. Reduce or stop therapy if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Frequently asked questions
Can I take Dextroamphetamine transdermal with Mirabegron?
MediHelp rates the interaction as moderate. Dextroamphetamine transdermal and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dextroamphetamine is partly metabolized by CYP2D6, so mirabegron may increase amphetamine exposure. This could heighten sympathomimetic effects and the risk of serotonin syndrome, although the clinical impact is likely modest.
How serious is the interaction between Dextroamphetamine transdermal and Mirabegron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a lower amphetamine dose and monitor heart rate, blood pressure and signs of serotonin toxicity. Reduce or stop therapy if symptoms occur.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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