Drug interactions
Dextromethorphan + Imlunestrant
Severity: Minor
Dextromethorphan and Imlunestrant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imlunestrant weakly inhibits CYP2D6, which increases exposure to dextromethorphan, a sensitive CYP2D6 substrate. This may lead to more dextromethorphan-related adverse effects such as dizziness or drowsiness.
What this interaction means in plain words
Dextromethorphan and Imlunestrant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dextromethorphan belongs to Respiratory; Imlunestrant belongs to Oncology.
Why it happens
CYP2D6 inhibition by imlunestrant reduces dextromethorphan metabolism.
What to do
Monitor for dextromethorphan adverse effects and use the lowest effective dose. Similar caution applies to other CYP2D6 substrates with a narrow therapeutic index.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imlunestrant
- Carbamazepine + Imlunestrant Major
- Imlunestrant + Itraconazole Major
- Digoxin + Imlunestrant Moderate
- Imlunestrant + Rosuvastatin Moderate
Other interactions of Dextromethorphan
- Dextromethorphan + Isocarboxazid Contraindicated
- Dextromethorphan + Linezolid Contraindicated
- Dextromethorphan + Phenelzine Contraindicated
- Dextromethorphan + Rasagiline Contraindicated
- Dextromethorphan + Safinamide Contraindicated
- Dextromethorphan + Selegiline Contraindicated
Frequently asked questions
Can I take Dextromethorphan with Imlunestrant?
MediHelp rates the interaction as minor. Dextromethorphan and Imlunestrant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Imlunestrant weakly inhibits CYP2D6, which increases exposure to dextromethorphan, a sensitive CYP2D6 substrate. This may lead to more dextromethorphan-related adverse effects such as dizziness or drowsiness.
How serious is the interaction between Dextromethorphan and Imlunestrant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dextromethorphan adverse effects and use the lowest effective dose. Similar caution applies to other CYP2D6 substrates with a narrow therapeutic index.
What other medicines interact with Imlunestrant?
MediHelp also lists interactions of Imlunestrant with, for example, Carbamazepine, Itraconazole, Digoxin. The full list is on the Imlunestrant page.
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