Drug interactions
Imlunestrant + Itraconazole
Severity: Major
Imlunestrant and Itraconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole raises imlunestrant exposure roughly two-fold, which may increase adverse reactions.
What this interaction means in plain words
Imlunestrant and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Imlunestrant belongs to Oncology; Itraconazole belongs to Anti Fungals.
Why it happens
Itraconazole strongly inhibits CYP3A4, decreasing imlunestrant metabolism.
What to do
Avoid combination, or reduce the imlunestrant dose per labeling and monitor for adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Imlunestrant
- Carbamazepine + Imlunestrant Major
- Digoxin + Imlunestrant Moderate
- Imlunestrant + Rosuvastatin Moderate
- Dextromethorphan + Imlunestrant Minor
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Imlunestrant with Itraconazole?
MediHelp rates the interaction as major. Imlunestrant and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole raises imlunestrant exposure roughly two-fold, which may increase adverse reactions.
How serious is the interaction between Imlunestrant and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination, or reduce the imlunestrant dose per labeling and monitor for adverse effects.
What other medicines interact with Imlunestrant?
MediHelp also lists interactions of Imlunestrant with, for example, Carbamazepine, Digoxin, Rosuvastatin. The full list is on the Imlunestrant page.
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