Drug interactions
Dextromethorphan + Nilotinib
Severity: Minor
Dextromethorphan and Nilotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP2D6 in vitro and could increase dextromethorphan concentrations. Clinical impact is uncertain and probably small at usual doses.
What this interaction means in plain words
Dextromethorphan and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dextromethorphan belongs to Respiratory; Nilotinib belongs to Oncology.
Why it happens
Nilotinib inhibits CYP2D6, reducing dextromethorphan clearance.
What to do
No routine adjustment is needed; monitor for CNS adverse effects with repeated or high-dose dextromethorphan.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dextromethorphan
- Dextromethorphan + Isocarboxazid Contraindicated
- Dextromethorphan + Linezolid Contraindicated
- Dextromethorphan + Phenelzine Contraindicated
- Dextromethorphan + Rasagiline Contraindicated
- Dextromethorphan + Safinamide Contraindicated
- Dextromethorphan + Selegiline Contraindicated
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Dextromethorphan with Nilotinib?
MediHelp rates the interaction as minor. Dextromethorphan and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nilotinib inhibits CYP2D6 in vitro and could increase dextromethorphan concentrations. Clinical impact is uncertain and probably small at usual doses.
How serious is the interaction between Dextromethorphan and Nilotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for CNS adverse effects with repeated or high-dose dextromethorphan.
What other medicines interact with Dextromethorphan?
MediHelp also lists interactions of Dextromethorphan with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Dextromethorphan page.
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