Drug interactions
Dextromethorphan + Pazopanib
Severity: Minor
Dextromethorphan and Pazopanib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib inhibits CYP2D6 in vitro and may increase exposure to dextromethorphan. This could heighten central nervous system effects such as dizziness and drowsiness.
What this interaction means in plain words
Dextromethorphan and Pazopanib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dextromethorphan belongs to Respiratory; Pazopanib belongs to Oncology.
Why it happens
Pazopanib inhibits CYP2D6, reducing the metabolism of dextromethorphan.
What to do
Monitor for dextromethorphan adverse effects and use the lowest effective dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dextromethorphan
- Dextromethorphan + Isocarboxazid Contraindicated
- Dextromethorphan + Linezolid Contraindicated
- Dextromethorphan + Phenelzine Contraindicated
- Dextromethorphan + Rasagiline Contraindicated
- Dextromethorphan + Safinamide Contraindicated
- Dextromethorphan + Selegiline Contraindicated
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Dextromethorphan with Pazopanib?
MediHelp rates the interaction as minor. Dextromethorphan and Pazopanib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pazopanib inhibits CYP2D6 in vitro and may increase exposure to dextromethorphan. This could heighten central nervous system effects such as dizziness and drowsiness.
How serious is the interaction between Dextromethorphan and Pazopanib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dextromethorphan adverse effects and use the lowest effective dose.
What other medicines interact with Dextromethorphan?
MediHelp also lists interactions of Dextromethorphan with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Dextromethorphan page.
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