Drug interactions
DHEA herbal + Midazolam
Severity: Minor
DHEA herbal and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
DHEA has been suggested to affect CYP3A4 activity, which could alter midazolam exposure. The evidence is limited and the clinical significance is uncertain.
What this interaction means in plain words
DHEA herbal and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible modulation of CYP3A4 activity by DHEA; not well established.
What to do
No routine dose change; monitor sedation response when midazolam is given to patients taking DHEA supplements.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take DHEA herbal with Midazolam?
MediHelp rates the interaction as minor. DHEA herbal and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. DHEA has been suggested to affect CYP3A4 activity, which could alter midazolam exposure. The evidence is limited and the clinical significance is uncertain.
How serious is the interaction between DHEA herbal and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; monitor sedation response when midazolam is given to patients taking DHEA supplements.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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