Drug interactions
Diamorphine + Haloperidol
Severity: Moderate
Diamorphine and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diamorphine (heroin) combined with haloperidol produces additive sedation and may deepen respiratory depression and hypotension. This combination is used in palliative care, where it is generally manageable with careful titration.
What this interaction means in plain words
Diamorphine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid agonism and antipsychotic sedation.
What to do
Titrate both drugs cautiously and monitor sedation level, respiratory rate and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Diamorphine with Haloperidol?
MediHelp rates the interaction as moderate. Diamorphine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diamorphine (heroin) combined with haloperidol produces additive sedation and may deepen respiratory depression and hypotension. This combination is used in palliative care, where it is generally manageable with careful titration.
How serious is the interaction between Diamorphine and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate both drugs cautiously and monitor sedation level, respiratory rate and blood pressure.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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