Drug interactions
Diazepam + Doxepin
Severity: Moderate
Diazepam and Doxepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is a sedating tricyclic antidepressant and adds to diazepam-induced drowsiness and psychomotor impairment. Risk is higher in older adults and with overdose.
What this interaction means in plain words
Diazepam and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Doxepin belongs to Dermatology.
Why it happens
Additive CNS depression from H1 antagonism and anticholinergic effects with GABA-A potentiation.
What to do
Monitor sedation and fall risk, and use the lowest effective doses, especially in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Diazepam with Doxepin?
MediHelp rates the interaction as moderate. Diazepam and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is a sedating tricyclic antidepressant and adds to diazepam-induced drowsiness and psychomotor impairment. Risk is higher in older adults and with overdose.
How serious is the interaction between Diazepam and Doxepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and fall risk, and use the lowest effective doses, especially in elderly patients.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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