Drug interactions
Diazepam + Gabapentin enacarbil
Severity: Moderate
Diazepam and Gabapentin enacarbil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS, and concurrent use increases sedation, dizziness and the risk of respiratory depression, especially in older patients or those with lung disease.
What this interaction means in plain words
Diazepam and Gabapentin enacarbil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Gabapentin enacarbil belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A modulation and gabapentinoid activity.
What to do
Use the lowest effective doses and monitor for sedation and respiratory depression. Counsel patients about driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Diazepam with Gabapentin enacarbil?
MediHelp rates the interaction as moderate. Diazepam and Gabapentin enacarbil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the CNS, and concurrent use increases sedation, dizziness and the risk of respiratory depression, especially in older patients or those with lung disease.
How serious is the interaction between Diazepam and Gabapentin enacarbil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression. Counsel patients about driving.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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