Drug interactions
Diazepam + Maprotiline
Severity: Moderate
Diazepam and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are sedating, and combined use can increase drowsiness, impaired psychomotor performance and anticholinergic-type effects. Maprotiline also lowers the seizure threshold, which may be relevant in patients with seizure disorders.
What this interaction means in plain words
Diazepam and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and the sedative antihistaminic effects of the tetracyclic antidepressant.
What to do
Monitor for oversedation and falls, and start with lower doses in older adults. Avoid alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Diazepam with Maprotiline?
MediHelp rates the interaction as moderate. Diazepam and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are sedating, and combined use can increase drowsiness, impaired psychomotor performance and anticholinergic-type effects. Maprotiline also lowers the seizure threshold, which may be relevant in patients with seizure disorders.
How serious is the interaction between Diazepam and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and falls, and start with lower doses in older adults. Avoid alcohol and other sedatives.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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