Drug interactions
Diazepam + Metaxalone
Severity: Moderate
Diazepam and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metaxalone causes drowsiness and dizziness, and with diazepam these effects can be increased, leading to impaired alertness and a higher risk of falls. The combination is usually manageable but needs care in older or frail patients.
What this interaction means in plain words
Diazepam and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects.
What to do
Use the lowest effective doses for the shortest duration and monitor for excessive sedation. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Metaxalone
Frequently asked questions
Can I take Diazepam with Metaxalone?
MediHelp rates the interaction as moderate. Diazepam and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metaxalone causes drowsiness and dizziness, and with diazepam these effects can be increased, leading to impaired alertness and a higher risk of falls. The combination is usually manageable but needs care in older or frail patients.
How serious is the interaction between Diazepam and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest duration and monitor for excessive sedation. Advise patients to avoid driving and alcohol.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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