Drug interactions
Diazepam + Mifepristone
Severity: Moderate
Diazepam and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4, which can raise diazepam levels and lead to increased sedation and psychomotor impairment. The effect is likely greater with prolonged mifepristone dosing than with a single dose.
What this interaction means in plain words
Diazepam and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Mifepristone belongs to Endocrine.
Why it happens
CYP3A4 inhibition by mifepristone reduces diazepam metabolism.
What to do
Monitor for excess sedation and consider lowering the diazepam dose during chronic mifepristone use. A benzodiazepine not dependent on CYP3A4 may be preferred.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Diazepam with Mifepristone?
MediHelp rates the interaction as moderate. Diazepam and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4, which can raise diazepam levels and lead to increased sedation and psychomotor impairment. The effect is likely greater with prolonged mifepristone dosing than with a single dose.
How serious is the interaction between Diazepam and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and consider lowering the diazepam dose during chronic mifepristone use. A benzodiazepine not dependent on CYP3A4 may be preferred.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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