Drug interactions
Diazepam + Rifapentine
Severity: Moderate
Diazepam and Rifapentine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces hepatic enzymes and can substantially lower diazepam concentrations, reducing anxiolytic, sedative or anticonvulsant effect. Effects may persist for some time after rifapentine is stopped.
What this interaction means in plain words
Diazepam and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Rifapentine belongs to Anti Bacterial.
Why it happens
Induction of CYP3A4 and CYP2C19 by rifapentine, increasing diazepam clearance.
What to do
Monitor clinical response and increase the diazepam dose if effect is lost. Reduce the dose again when rifapentine is discontinued to avoid accumulation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Diazepam with Rifapentine?
MediHelp rates the interaction as moderate. Diazepam and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine induces hepatic enzymes and can substantially lower diazepam concentrations, reducing anxiolytic, sedative or anticonvulsant effect. Effects may persist for some time after rifapentine is stopped.
How serious is the interaction between Diazepam and Rifapentine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and increase the diazepam dose if effect is lost. Reduce the dose again when rifapentine is discontinued to avoid accumulation.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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