Drug interactions
Diazepam + Sparsentan
Severity: Minor
Diazepam and Sparsentan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan is a weak inducer of CYP2C19 and CYP3A4 and may lower exposure to diazepam and its active metabolite. This may reduce diazepam efficacy modestly.
What this interaction means in plain words
Diazepam and Sparsentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diazepam belongs to Musculoskeletal; Sparsentan belongs to Genitourinary.
Why it happens
Induction of CYP2C19 and CYP3A4 by sparsentan increases diazepam metabolism.
What to do
Monitor clinical response to diazepam and increase the dose only if effect is diminished.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diazepam
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Diazepam with Sparsentan?
MediHelp rates the interaction as minor. Diazepam and Sparsentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sparsentan is a weak inducer of CYP2C19 and CYP3A4 and may lower exposure to diazepam and its active metabolite. This may reduce diazepam efficacy modestly.
How serious is the interaction between Diazepam and Sparsentan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to diazepam and increase the dose only if effect is diminished.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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