Drug interactions
Diazepam + Zafirlukast
Severity: Minor
Diazepam and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diazepam is metabolized by CYP3A4 and CYP2C19, so zafirlukast could modestly raise its levels. This might increase sedation and psychomotor impairment, but the effect is expected to be small.
What this interaction means in plain words
Diazepam and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diazepam belongs to Musculoskeletal; Zafirlukast belongs to Respiratory.
Why it happens
Weak CYP3A4 inhibition by zafirlukast may slightly reduce diazepam clearance.
What to do
Monitor for excess drowsiness and reduce the diazepam dose if sedation develops. Counsel the patient about driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Diazepam
Frequently asked questions
Can I take Diazepam with Zafirlukast?
MediHelp rates the interaction as minor. Diazepam and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diazepam is metabolized by CYP3A4 and CYP2C19, so zafirlukast could modestly raise its levels. This might increase sedation and psychomotor impairment, but the effect is expected to be small.
How serious is the interaction between Diazepam and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess drowsiness and reduce the diazepam dose if sedation develops. Counsel the patient about driving.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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