Drug interactions
Diazepam + Ziprasidone
Severity: Moderate
Diazepam and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination can increase sedation, dizziness and impaired alertness. Orthostatic hypotension may also occur, and ziprasidone's QT effect remains an independent consideration.
What this interaction means in plain words
Diazepam and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazepam belongs to Musculoskeletal; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation by diazepam and H1 and alpha-1 blockade by ziprasidone.
What to do
Use the lowest effective doses and monitor for sedation and orthostatic hypotension. Counsel patients against driving and alcohol use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Diazepam with Ziprasidone?
MediHelp rates the interaction as moderate. Diazepam and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination can increase sedation, dizziness and impaired alertness. Orthostatic hypotension may also occur, and ziprasidone's QT effect remains an independent consideration.
How serious is the interaction between Diazepam and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and orthostatic hypotension. Counsel patients against driving and alcohol use.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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