Drug interactions
Diazepam intranasal + Eslicarbazepine
Severity: Moderate
Diazepam intranasal and Eslicarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause sedation, and additive CNS and respiratory depression is possible. Eslicarbazepine may also alter diazepam levels through opposing effects on CYP3A4 and CYP2C19.
What this interaction means in plain words
Diazepam intranasal and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression plus CYP3A4 induction and CYP2C19 inhibition by eslicarbazepine altering diazepam clearance.
What to do
Monitor for sedation, respiratory depression, and rescue-treatment efficacy. Counsel caregivers to watch for prolonged drowsiness after a dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Diazepam intranasal and Eslicarbazepine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Diazepam intranasal with Eslicarbazepine?
MediHelp rates the interaction as moderate. Diazepam intranasal and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause sedation, and additive CNS and respiratory depression is possible. Eslicarbazepine may also alter diazepam levels through opposing effects on CYP3A4 and CYP2C19.
How serious is the interaction between Diazepam intranasal and Eslicarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, respiratory depression, and rescue-treatment efficacy. Counsel caregivers to watch for prolonged drowsiness after a dose.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
