Drug interactions
Diazepam intranasal + Fluvoxamine
Severity: Moderate
Diazepam intranasal and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine inhibits CYP2C19 and CYP3A4, which metabolize diazepam, and can slow its clearance and prolong its effect. This can increase sedation, psychomotor impairment and respiratory depression.
What this interaction means in plain words
Diazepam intranasal and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fluvoxamine inhibits CYP2C19 and CYP3A4 metabolism of diazepam, raising its exposure.
What to do
Monitor for excessive sedation and respiratory depression, and reduce the diazepam dose or lengthen the dosing interval if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Diazepam intranasal with Fluvoxamine?
MediHelp rates the interaction as moderate. Diazepam intranasal and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine inhibits CYP2C19 and CYP3A4, which metabolize diazepam, and can slow its clearance and prolong its effect. This can increase sedation, psychomotor impairment and respiratory depression.
How serious is the interaction between Diazepam intranasal and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and respiratory depression, and reduce the diazepam dose or lengthen the dosing interval if needed.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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