Drug interactions
Diazepam intranasal + Haloperidol
Severity: Moderate
Diazepam intranasal and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol is a CYP3A4 substrate and only a weak inhibitor of it, so a clinically meaningful rise in diazepam exposure is unlikely. The more relevant effect is additive sedation from the combination of a benzodiazepine and an antipsychotic.
What this interaction means in plain words
Diazepam intranasal and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression; weak possible CYP3A4 inhibition by haloperidol.
What to do
Monitor for excessive sedation and respiratory depression, especially in older adults or with other CNS depressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Diazepam intranasal with Haloperidol?
MediHelp rates the interaction as moderate. Diazepam intranasal and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol is a CYP3A4 substrate and only a weak inhibitor of it, so a clinically meaningful rise in diazepam exposure is unlikely. The more relevant effect is additive sedation from the combination of a benzodiazepine and an antipsychotic.
How serious is the interaction between Diazepam intranasal and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and respiratory depression, especially in older adults or with other CNS depressants.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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