Drug interactions
Diazepam intranasal + Itraconazole
Severity: Moderate
Diazepam intranasal and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole slows diazepam elimination, raising diazepam levels and prolonging sedation. Excessive sedation and respiratory depression may result.
What this interaction means in plain words
Diazepam intranasal and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Strong CYP3A4 inhibition reduces the metabolic clearance of diazepam.
What to do
Monitor for excessive sedation and respiratory depression, particularly if repeat doses are needed. Consider a lower diazepam dose or an alternative benzodiazepine not dependent on CYP3A4, such as lorazepam.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Diazepam intranasal and Itraconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Diazepam intranasal with Itraconazole?
MediHelp rates the interaction as moderate. Diazepam intranasal and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole slows diazepam elimination, raising diazepam levels and prolonging sedation. Excessive sedation and respiratory depression may result.
How serious is the interaction between Diazepam intranasal and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and respiratory depression, particularly if repeat doses are needed. Consider a lower diazepam dose or an alternative benzodiazepine not dependent on CYP3A4, such as lorazepam.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
