Drug interactions
Diazepam intranasal + Omeprazole
Severity: Moderate
Diazepam intranasal and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diazepam is partly cleared through CYP2C19, which omeprazole inhibits. Diazepam elimination can slow, increasing sedation and psychomotor impairment. For a rescue dose product used intermittently, the effect is generally limited.
What this interaction means in plain words
Diazepam intranasal and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Omeprazole inhibits CYP2C19-mediated demethylation of diazepam, reducing its clearance.
What to do
Monitor for excess sedation and respiratory depression after diazepam doses. Counsel patients about prolonged drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Frequently asked questions
Can I take Diazepam intranasal with Omeprazole?
MediHelp rates the interaction as moderate. Diazepam intranasal and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diazepam is partly cleared through CYP2C19, which omeprazole inhibits. Diazepam elimination can slow, increasing sedation and psychomotor impairment. For a rescue dose product used intermittently, the effect is generally limited.
How serious is the interaction between Diazepam intranasal and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and respiratory depression after diazepam doses. Counsel patients about prolonged drowsiness.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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