Drug interactions
Diazepam intranasal + Ribociclib
Severity: Moderate
Diazepam intranasal and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate-to-strong CYP3A4 inhibitor at clinical doses and diazepam is partly metabolized by CYP3A4. Diazepam exposure may rise, causing deeper or longer sedation and respiratory depression.
What this interaction means in plain words
Diazepam intranasal and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated diazepam metabolism by ribociclib.
What to do
Monitor for excessive sedation and respiratory depression, and avoid additional CNS depressants. Consider fewer repeated intranasal doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Diazepam intranasal with Ribociclib?
MediHelp rates the interaction as moderate. Diazepam intranasal and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate-to-strong CYP3A4 inhibitor at clinical doses and diazepam is partly metabolized by CYP3A4. Diazepam exposure may rise, causing deeper or longer sedation and respiratory depression.
How serious is the interaction between Diazepam intranasal and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and respiratory depression, and avoid additional CNS depressants. Consider fewer repeated intranasal doses.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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