Drug interactions
Diazepam intranasal + Voriconazole
Severity: Moderate
Diazepam intranasal and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole can slow diazepam elimination, increasing sedation and risk of respiratory depression. Effects may be prolonged.
What this interaction means in plain words
Diazepam intranasal and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Voriconazole inhibits CYP2C19 and CYP3A4, the main enzymes metabolizing diazepam.
What to do
Monitor for excessive sedation and respiratory depression, and consider a lower diazepam dose or longer dosing interval.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Diazepam intranasal with Voriconazole?
MediHelp rates the interaction as moderate. Diazepam intranasal and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole can slow diazepam elimination, increasing sedation and risk of respiratory depression. Effects may be prolonged.
How serious is the interaction between Diazepam intranasal and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and respiratory depression, and consider a lower diazepam dose or longer dosing interval.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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