Drug interactions
Diazoxide + Eprosartan-hydrochlorothiazide
Severity: Moderate
Diazoxide and Eprosartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both thiazide diuretics and diazoxide can raise blood glucose, and combined use may cause or worsen hyperglycemia. Both can also cause hyperuricemia and additive hypotension.
What this interaction means in plain words
Diazoxide and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazoxide belongs to Miscellaneous; Eprosartan-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive suppression of insulin secretion and impaired glucose tolerance, with additive hypotensive effects.
What to do
Monitor blood glucose closely and adjust antidiabetic therapy or diazoxide dose as needed. Monitor blood pressure and uric acid.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Diazoxide
Frequently asked questions
Can I take Diazoxide with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Diazoxide and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both thiazide diuretics and diazoxide can raise blood glucose, and combined use may cause or worsen hyperglycemia. Both can also cause hyperuricemia and additive hypotension.
How serious is the interaction between Diazoxide and Eprosartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and adjust antidiabetic therapy or diazoxide dose as needed. Monitor blood pressure and uric acid.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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