Drug interactions
Diazoxide + Hydralazine
Severity: Moderate
Diazoxide and Hydralazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are arteriolar vasodilators, so combining them can cause additive and sometimes profound hypotension. Reflex tachycardia and fluid retention may also be amplified.
What this interaction means in plain words
Diazoxide and Hydralazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazoxide belongs to Miscellaneous; Hydralazine belongs to Cardiovascular.
Why it happens
Additive vasodilation: diazoxide opens potassium channels in vascular smooth muscle while hydralazine acts as a direct arteriolar dilator.
What to do
Monitor blood pressure and heart rate closely and reduce doses if hypotension occurs. Avoid giving parenteral diazoxide for hypertensive emergency shortly after other potent vasodilators unless closely monitored.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Other interactions of Diazoxide
Frequently asked questions
Can I take Diazoxide with Hydralazine?
MediHelp rates the interaction as moderate. Diazoxide and Hydralazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are arteriolar vasodilators, so combining them can cause additive and sometimes profound hypotension. Reflex tachycardia and fluid retention may also be amplified.
How serious is the interaction between Diazoxide and Hydralazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate closely and reduce doses if hypotension occurs. Avoid giving parenteral diazoxide for hypertensive emergency shortly after other potent vasodilators unless closely monitored.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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