Drug interactions
Diazoxide + Hydrochlorothiazide-telmisartan
Severity: Moderate
Diazoxide and Hydrochlorothiazide-telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides and diazoxide both raise blood glucose, and together the hyperglycemia can be pronounced. Their blood pressure lowering effects may also add up, and hyperuricemia can be enhanced.
What this interaction means in plain words
Diazoxide and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazoxide belongs to Miscellaneous; Hydrochlorothiazide-telmisartan belongs to Cardiovascular.
Why it happens
Additive hyperglycemic effects: diazoxide opens pancreatic potassium channels to suppress insulin release, and thiazides impair glucose tolerance.
What to do
Monitor blood glucose and blood pressure closely. Adjust diazoxide or antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Diazoxide
Frequently asked questions
Can I take Diazoxide with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as moderate. Diazoxide and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides and diazoxide both raise blood glucose, and together the hyperglycemia can be pronounced. Their blood pressure lowering effects may also add up, and hyperuricemia can be enhanced.
How serious is the interaction between Diazoxide and Hydrochlorothiazide-telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and blood pressure closely. Adjust diazoxide or antidiabetic therapy as needed.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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