Drug interactions
Diazoxide + Hydrochlorothiazide-valsartan
Severity: Moderate
Diazoxide and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diazoxide and thiazide diuretics both raise blood glucose, and combined use may enhance hyperglycemia. Both can also lower blood pressure and potassium, so hypotension and electrolyte disturbance may be additive.
What this interaction means in plain words
Diazoxide and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazoxide belongs to Miscellaneous; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Additive hyperglycemic effect through suppressed insulin release and reduced insulin sensitivity, plus additive vasodilatory and hypotensive effects.
What to do
Monitor blood glucose, potassium and blood pressure, and adjust glucose-lowering therapy or the diazoxide dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Diazoxide
Frequently asked questions
Can I take Diazoxide with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Diazoxide and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diazoxide and thiazide diuretics both raise blood glucose, and combined use may enhance hyperglycemia. Both can also lower blood pressure and potassium, so hypotension and electrolyte disturbance may be additive.
How serious is the interaction between Diazoxide and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, potassium and blood pressure, and adjust glucose-lowering therapy or the diazoxide dose if needed.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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