Drug interactions
Diazoxide + Insulin degludec
Severity: Moderate
Diazoxide and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diazoxide raises blood glucose and can cause marked hyperglycemia in patients with diabetes. It directly opposes the glucose-lowering effect of insulin degludec and may cause loss of control.
What this interaction means in plain words
Diazoxide and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazoxide belongs to Miscellaneous; Insulin degludec belongs to Endocrine.
Why it happens
Diazoxide opens pancreatic beta-cell potassium channels, which suppresses insulin secretion, and it also raises catecholamine release, antagonizing insulin action.
What to do
Monitor blood glucose closely and increase the insulin degludec dose as needed. Reduce the insulin dose when diazoxide is stopped to avoid hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec
Other interactions of Diazoxide
Frequently asked questions
Can I take Diazoxide with Insulin degludec?
MediHelp rates the interaction as moderate. Diazoxide and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diazoxide raises blood glucose and can cause marked hyperglycemia in patients with diabetes. It directly opposes the glucose-lowering effect of insulin degludec and may cause loss of control.
How serious is the interaction between Diazoxide and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and increase the insulin degludec dose as needed. Reduce the insulin dose when diazoxide is stopped to avoid hypoglycemia.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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