Drug interactions
Diazoxide + Metformin-repaglinide
Severity: Moderate
Diazoxide and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral diazoxide causes hyperglycemia by suppressing insulin secretion, directly opposing metformin and repaglinide. Glucose control may deteriorate markedly, particularly with repaglinide, which acts by stimulating insulin release.
What this interaction means in plain words
Diazoxide and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diazoxide belongs to Miscellaneous; Metformin-repaglinide belongs to Endocrine.
Why it happens
Diazoxide opens pancreatic beta-cell KATP channels, inhibiting insulin release and counteracting the glucose-lowering drugs.
What to do
Monitor blood glucose frequently and adjust antidiabetic therapy. Avoid combining with repaglinide where possible because it works on the same channel and the effects directly oppose each other.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Diazoxide
Frequently asked questions
Can I take Diazoxide with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Diazoxide and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral diazoxide causes hyperglycemia by suppressing insulin secretion, directly opposing metformin and repaglinide. Glucose control may deteriorate markedly, particularly with repaglinide, which acts by stimulating insulin release.
How serious is the interaction between Diazoxide and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently and adjust antidiabetic therapy. Avoid combining with repaglinide where possible because it works on the same channel and the effects directly oppose each other.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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