Drug interactions
Dichloralphenazone + Midazolam
Severity: Major
Dichloralphenazone and Midazolam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichloralphenazone is metabolised to chloral hydrate, a sedative-hypnotic, so combining it with midazolam increases sedation and the risk of respiratory depression. Airway obstruction and hypoxia may occur, especially with higher doses or in vulnerable patients.
What this interaction means in plain words
Dichloralphenazone and Midazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from combined GABAergic sedative effects.
What to do
Avoid combining where possible. If necessary, reduce doses and monitor respiratory rate and oxygen saturation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Dichloralphenazone with Midazolam?
MediHelp rates the interaction as major. Dichloralphenazone and Midazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dichloralphenazone is metabolised to chloral hydrate, a sedative-hypnotic, so combining it with midazolam increases sedation and the risk of respiratory depression. Airway obstruction and hypoxia may occur, especially with higher doses or in vulnerable patients.
How serious is the interaction between Dichloralphenazone and Midazolam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible. If necessary, reduce doses and monitor respiratory rate and oxygen saturation.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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