Drug interactions
Dichlorphenamide + Ethacrynic acid
Severity: Moderate
Dichlorphenamide and Ethacrynic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs increase renal potassium excretion, so together they can cause significant hypokalemia. Low potassium can cause weakness and arrhythmias, and ethacrynic acid is a potent loop diuretic.
What this interaction means in plain words
Dichlorphenamide and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Ethacrynic acid belongs to Cardiovascular.
Why it happens
Additive kaliuresis from carbonic anhydrase inhibition and loop diuretic action.
What to do
Monitor serum potassium and bicarbonate regularly and replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dichlorphenamide
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Dichlorphenamide with Ethacrynic acid?
MediHelp rates the interaction as moderate. Dichlorphenamide and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs increase renal potassium excretion, so together they can cause significant hypokalemia. Low potassium can cause weakness and arrhythmias, and ethacrynic acid is a potent loop diuretic.
How serious is the interaction between Dichlorphenamide and Ethacrynic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate regularly and replace potassium as needed.
What other medicines interact with Dichlorphenamide?
MediHelp also lists interactions of Dichlorphenamide with, for example, Acetazolamide, Acetylsalicylic acid, Ammonium chloride. The full list is on the Dichlorphenamide page.
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