Drug interactions
Dichlorphenamide + Furosemide
Severity: Moderate
Dichlorphenamide and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents increase renal potassium loss, so using them together may cause pronounced hypokalemia. Dichlorphenamide also causes metabolic acidosis and may worsen electrolyte disturbances.
What this interaction means in plain words
Dichlorphenamide and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Furosemide belongs to Cardiovascular.
Why it happens
Additive kaliuresis from carbonic anhydrase inhibition (increased distal bicarbonate and sodium delivery) and loop diuretic action.
What to do
Monitor serum potassium and bicarbonate regularly, and supplement potassium as required. Reassess the need for the diuretic if hypokalemia persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Furosemide?
MediHelp rates the interaction as moderate. Dichlorphenamide and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents increase renal potassium loss, so using them together may cause pronounced hypokalemia. Dichlorphenamide also causes metabolic acidosis and may worsen electrolyte disturbances.
How serious is the interaction between Dichlorphenamide and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate regularly, and supplement potassium as required. Reassess the need for the diuretic if hypokalemia persists.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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