Drug interactions
Dichlorphenamide + Gemcitabine
Severity: Moderate
Dichlorphenamide and Gemcitabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide lowers serum potassium and can cause metabolic acidosis. Gemcitabine can cause nausea, vomiting and renal effects, which may worsen electrolyte and acid-base disturbance.
What this interaction means in plain words
Dichlorphenamide and Gemcitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Gemcitabine belongs to Oncology.
Why it happens
Additive potassium depletion and acid-base disturbance, partly through gastrointestinal and renal effects of the chemotherapy.
What to do
Monitor serum potassium, bicarbonate and renal function, and replace potassium as needed. Reassess dichlorphenamide if acidosis worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dichlorphenamide and Gemcitabine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Gemcitabine
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Gemcitabine?
MediHelp rates the interaction as moderate. Dichlorphenamide and Gemcitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide lowers serum potassium and can cause metabolic acidosis. Gemcitabine can cause nausea, vomiting and renal effects, which may worsen electrolyte and acid-base disturbance.
How serious is the interaction between Dichlorphenamide and Gemcitabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, bicarbonate and renal function, and replace potassium as needed. Reassess dichlorphenamide if acidosis worsens.
What other medicines interact with Gemcitabine?
MediHelp also lists interactions of Gemcitabine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Gemcitabine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
