Drug interactions
Dichlorphenamide + Gemifloxacin
Severity: Moderate
Dichlorphenamide and Gemifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide commonly causes hypokalemia and metabolic acidosis, and low potassium increases susceptibility to QT prolongation and torsades de pointes. Gemifloxacin itself can prolong the QT interval, so the combination adds arrhythmic risk.
What this interaction means in plain words
Dichlorphenamide and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Gemifloxacin belongs to Anti Bacterial.
Why it happens
Dichlorphenamide-induced hypokalemia potentiates the QT-prolonging effect of gemifloxacin.
What to do
Check serum potassium and bicarbonate before and during therapy and correct deficits. Consider ECG monitoring if other QT risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Gemifloxacin?
MediHelp rates the interaction as moderate. Dichlorphenamide and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide commonly causes hypokalemia and metabolic acidosis, and low potassium increases susceptibility to QT prolongation and torsades de pointes. Gemifloxacin itself can prolong the QT interval, so the combination adds arrhythmic risk.
How serious is the interaction between Dichlorphenamide and Gemifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and bicarbonate before and during therapy and correct deficits. Consider ECG monitoring if other QT risk factors exist.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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