Drug interactions
Dichlorphenamide + Gentamicin
Severity: Moderate
Dichlorphenamide and Gentamicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide, a carbonic anhydrase inhibitor, increases urinary potassium loss and can cause metabolic acidosis. With gentamicin, which can also waste potassium and magnesium, hypokalemia may be more pronounced.
What this interaction means in plain words
Dichlorphenamide and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Gentamicin belongs to Anti Bacterial.
Why it happens
Additive renal potassium wasting from carbonic anhydrase inhibition and aminoglycoside tubular toxicity.
What to do
Monitor serum potassium, magnesium and bicarbonate, and correct deficits promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Dichlorphenamide with Gentamicin?
MediHelp rates the interaction as moderate. Dichlorphenamide and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide, a carbonic anhydrase inhibitor, increases urinary potassium loss and can cause metabolic acidosis. With gentamicin, which can also waste potassium and magnesium, hypokalemia may be more pronounced.
How serious is the interaction between Dichlorphenamide and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, magnesium and bicarbonate, and correct deficits promptly.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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