Drug interactions
Dichlorphenamide + Iloperidone
Severity: Moderate
Dichlorphenamide and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide commonly lowers serum potassium, and hypokalemia increases the risk of QT-related arrhythmias. Iloperidone prolongs the QT interval, so combined use may raise the risk of torsades de pointes.
What this interaction means in plain words
Dichlorphenamide and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dichlorphenamide belongs to Miscellaneous; Iloperidone belongs to Central Nervous System.
Why it happens
Dichlorphenamide-induced hypokalemia and metabolic acidosis add to the QT-prolonging effect of iloperidone (pharmacodynamic).
What to do
Check serum potassium and bicarbonate at baseline and periodically, and correct hypokalemia promptly. Obtain an ECG if other QT risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dichlorphenamide
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Dichlorphenamide with Iloperidone?
MediHelp rates the interaction as moderate. Dichlorphenamide and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide commonly lowers serum potassium, and hypokalemia increases the risk of QT-related arrhythmias. Iloperidone prolongs the QT interval, so combined use may raise the risk of torsades de pointes.
How serious is the interaction between Dichlorphenamide and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and bicarbonate at baseline and periodically, and correct hypokalemia promptly. Obtain an ECG if other QT risk factors exist.
What other medicines interact with Dichlorphenamide?
MediHelp also lists interactions of Dichlorphenamide with, for example, Acetazolamide, Acetylsalicylic acid, Ammonium chloride. The full list is on the Dichlorphenamide page.
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